There are 123.61 miles from Anderson to Knoxville in northwest direction and 198 miles (318.65 kilometers) by car, following the US-74 W and US-64 Truck W route.
Anderson and Knoxville are 3 hours 30 mins far apart, if you drive non-stop .
This is the fastest route from Anderson, SC to Knoxville, TN. The halfway point is Canton, NC.
Anderson, SC and Knoxville, TN are in the same time zone (EDT). Current time in both locations is 4:38 pm.
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