There are 541.80 miles from Des Moines to Lexington in southeast direction and 662 miles (1,065.39 kilometers) by car, following the I-80 route.
Des Moines and Lexington are 10 hours 9 mins far apart, if you drive non-stop .
This is the fastest route from Des Moines, IA to Lexington, KY. The halfway point is Le Roy, IL.
Please note the time difference between Des Moines, IA and Lexington, KY is 1 hour. The current time in Des Moines is 3:24 pm and the current time in Lexington is 4:24 pm.
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