There are 225.49 miles from Jacksonville to Port Saint Lucie in southeast direction and 235 miles (378.20 kilometers) by car, following the I-95 S route.
Jacksonville and Port Saint Lucie are 3 hours 31 mins far apart, if you drive non-stop .
This is the fastest route from Jacksonville, FL to Port Saint Lucie, FL. The halfway point is Oak Hill, FL.
Jacksonville, FL and Port Saint Lucie, FL are in the same time zone (EDT). Current time in both locations is 10:38 pm.
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