There are 176.12 miles from Perryville to Syracuse in northwest direction and 237 miles (381.41 kilometers) by car, following the US-40 W route.
Perryville and Syracuse are 3 hours 41 mins far apart, if you drive non-stop .
This is the fastest route from Perryville, MO to Syracuse, MO. The halfway point is Warrenton, MO.
Perryville, MO and Syracuse, MO are in the same time zone (CDT). Current time in both locations is 8:19 pm.
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