There are 241.70 miles from Saint Louis to Louisville in east direction and 260 miles (418.43 kilometers) by car, following the I-64 E route.
Saint Louis and Louisville are 3 hours 55 mins far apart, if you drive non-stop .
This is the fastest route from Saint Louis, MO to Louisville, KY. The halfway point is Grayville, IL.
Please note the time difference between Saint Louis, MO and Louisville, KY is 1 hour. The current time in Saint Louis is 2:36 pm and the current time in Louisville is 3:36 pm.
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