There are 540.90 miles from Saint Louis to Mesquite in southwest direction and 638 miles (1,026.76 kilometers) by car, following the I-44 W route.
Saint Louis and Mesquite are 10 hours 3 mins far apart, if you drive non-stop .
This is the fastest route from Saint Louis, MO to Mesquite, TX. The halfway point is Peoria, OK.
Saint Louis, MO and Mesquite, TX are in the same time zone (CDT). Current time in both locations is 6:23 am.
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