There are 256.70 miles from San Antonio to Mesquite in northeast direction and 282 miles (453.84 kilometers) by car, following the I-35 N route.
San Antonio and Mesquite are 4 hours 22 mins far apart, if you drive non-stop .
This is the fastest route from San Antonio, TX to Mesquite, TX. The halfway point is Salado, TX.
San Antonio, TX and Mesquite, TX are in the same time zone (CDT). Current time in both locations is 1:50 am.
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