There are 2,532.28 miles from San Francisco to Port Saint Lucie in southeast direction and 2,968 miles (4,776.53 kilometers) by car, following the I-40 route.
San Francisco and Port Saint Lucie are 1 day 19 hours far apart, if you drive non-stop .
This is the fastest route from San Francisco, CA to Port Saint Lucie, FL. The halfway point is McLean, TX.
Please note the time difference between San Francisco, CA and Port Saint Lucie, FL is 3 hours. The current time in San Francisco is 10:30 pm (Mar 28) and the current time in Port Saint Lucie is 1:30 am (Mar 29).
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