There are 151.84 miles from Santa Fe to Adrian in southwest direction and 217 miles (349.23 kilometers) by car, following the I-70 W and US-40 W route.
Santa Fe and Adrian are 3 hours 44 mins far apart, if you drive non-stop .
This is the fastest route from Santa Fe, MO to Adrian, MO. The halfway point is Houstonia, MO.
Santa Fe, MO and Adrian, MO are in the same time zone (CDT). Current time in both locations is 5:42 pm.
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