There are 337.97 miles from Winston-Salem to Louisville in northwest direction and 462 miles (743.52 kilometers) by car, following the I-64 W route.
Winston-Salem and Louisville are 7 hours 17 mins far apart, if you drive non-stop .
This is the fastest route from Winston-Salem, NC to Louisville, KY. The halfway point is Milton, WV.
Winston-Salem, NC and Louisville, KY are in the same time zone (EDT). Current time in both locations is 8:40 am.
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