There are 548.75 miles from Buffalo to Knoxville in southwest direction and 684.42 miles (1,101.47 kilometers) by car, following the I-71 and I-75 route.
Buffalo and Knoxville are 9 hours 26 mins far apart, if you drive non-stop.
This is the fastest route from Buffalo, NY to Knoxville, TN. The halfway point is .
Buffalo, NY and Knoxville, TN are in the same time zone (EDT). Current time in both locations is 3:11 am.
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