There are 548.75 miles from Buffalo to Knoxville in southwest direction and 683 miles (1,099.18 kilometers) by car, following the I-71 and I-75 route.
Buffalo and Knoxville are 12 hours 51 mins far apart, if you drive non-stop.
This is the fastest route from Buffalo, NY to Knoxville, TN. The halfway point is Grandview Heights, OH.
Buffalo, NY and Knoxville, TN are in the same time zone (Eastern Daylight Time). Current time in both locations is 7:53 am.
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