There are 1,081.97 miles from Buffalo to Port Saint Lucie in south direction and 1,274 miles (2,050.30 kilometers) by car, following the I-95 route.
Buffalo and Port Saint Lucie are 23 hours 52 mins far apart, if you drive non-stop.
This is the fastest route from Buffalo, NY to Port Saint Lucie, FL. The halfway point is Huntersville, NC.
Buffalo, NY and Port Saint Lucie, FL are in the same time zone (Eastern Daylight Time). Current time in both locations is 10:58 pm.
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