There are 1,081.97 miles from Buffalo to Port Saint Lucie in south direction and 1,275.86 miles (2,053.30 kilometers) by car, following the I-95 route.
Buffalo and Port Saint Lucie are 17 hours 47 mins far apart, if you drive non-stop.
This is the fastest route from Buffalo, NY to Port Saint Lucie, FL. The halfway point is .
Buffalo, NY and Port Saint Lucie, FL are in the same time zone (EDT). Current time in both locations is 11:47 am.
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