There are 269.31 miles from Chicago to Louisville in southeast direction and 295 miles (474.76 kilometers) by car, following the I-65 route.
Chicago and Louisville are 5 hours 28 mins far apart, if you drive non-stop.
This is the fastest route from Chicago, IL to Louisville, KY. The halfway point is Thorntown, IN.
Please note the time difference between Chicago, IL and Louisville, KY is 1 hour. The current time in Chicago is 12:59 pm and the current time in Louisville is 1:59 pm.
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