There are 219.53 miles from Cincinnati to Knoxville in south direction and 251 miles (403.95 kilometers) by car, following the I-75 S route.
Cincinnati and Knoxville are 3 hours 46 mins far apart, if you drive non-stop.
This is the fastest route from Cincinnati, OH to Knoxville, TN. The halfway point is Wildie, KY.
Cincinnati, OH and Knoxville, TN are in the same time zone (EDT). Current time in both locations is 2:37 pm.
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