There are 280.65 miles from Clarksdale to Biloxi in southeast direction and 351 miles (564.88 kilometers) by car, following the I-55 S route.
Clarksdale and Biloxi are 5 hours 56 mins far apart, if you drive non-stop .
This is the fastest route from Clarksdale, MS to Biloxi, MS. The halfway point is Madison, MS.
Clarksdale, MS and Biloxi, MS are in the same time zone (CDT). Current time in both locations is 9:42 am.
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