There are 303.03 miles from Cleveland to Syracuse in northeast direction and 334 miles (537.52 kilometers) by car, following the I-90 route.
Cleveland and Syracuse are 6 hours 33 mins far apart, if you drive non-stop.
This is the fastest route from Cleveland, OH to Syracuse, NY. The halfway point is Derby, NY.
Cleveland, OH and Syracuse, NY are in the same time zone (Eastern Daylight Time). Current time in both locations is 2:05 pm.
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