There are 280.93 miles from Columbus to Knoxville in south direction and 358 miles (576.15 kilometers) by car, following the I-71 and I-75 route.
Columbus and Knoxville are 6 hours 39 mins far apart, if you drive non-stop.
This is the fastest route from Columbus, OH to Knoxville, TN. The halfway point is Georgetown, KY.
Columbus, OH and Knoxville, TN are in the same time zone (Eastern Daylight Time). Current time in both locations is 4:11 pm.
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