There are 410.24 miles from Des Moines to Indianapolis in southeast direction and 495.81 miles (797.93 kilometers) by car, following the I-80 route.
Des Moines and Indianapolis are 7 hours 13 mins far apart, if you drive non-stop.
This is the fastest route from Des Moines, IA to Indianapolis, IN. The halfway point is .
Please note the time difference between Des Moines, IA and Indianapolis, IN is 1 hour. The current time in Des Moines is 5:17 pm and the current time in Indianapolis is 6:17 pm.
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