There are 315.95 miles from Detroit to Louisville in southwest direction and 364.41 miles (586.46 kilometers) by car, following the I-75 route.
Detroit and Louisville are 5 hours 16 mins far apart, if you drive non-stop.
This is the fastest route from Detroit, MI to Louisville, KY. The halfway point is .
Detroit, MI and Louisville, KY are in the same time zone (EDT). Current time in both locations is 11:41 am.
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