There are 41.68 miles from Gainesville to Lake City in northwest direction and 46 miles (74.03 kilometers) by car, following the I-75 N route.
Gainesville and Lake City are 49 minutes far apart, if you drive non-stop .
This is the fastest route from Gainesville, FL to Lake City, FL. The halfway point is High Springs, FL.
Gainesville, FL and Lake City, FL are in the same time zone (EDT). Current time in both locations is 4:38 pm.
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