There are 355.78 miles from Huntsville to Defiance in northwest direction and 455 miles (732.25 kilometers) by car, following the I-24 W route.
Huntsville and Defiance are 7 hours 9 mins far apart, if you drive non-stop .
This is the fastest route from Huntsville, AL to Defiance, MO. The halfway point is Calvert City, KY.
Huntsville, AL and Defiance, MO are in the same time zone (CDT). Current time in both locations is 7:04 am.
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