There are 290.32 miles from Indianapolis to Knoxville in southeast direction and 357.65 miles by car, following the route.
Indianapolis and Knoxville are 5 hours 16 mins far apart, if you drive non-stop.
This is the fastest route from Indianapolis, IN to Knoxville, TN. The halfway point is .
Indianapolis, IN and Knoxville, TN are in the same time zone (EDT). Current time in both locations is 2:58 pm.
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