There are 289.99 miles from Indianapolis to Knoxville in southeast direction and 349 miles (561.66 kilometers) by car, following the I-75 route.
Indianapolis and Knoxville are 6 hours 33 mins far apart, if you drive non-stop.
This is the fastest route from Indianapolis, IN to Knoxville, TN. The halfway point is Bondville, KY.
Indianapolis, IN and Knoxville, TN are in the same time zone (Eastern Daylight Time). Current time in both locations is 1:14 am.
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