There are 123.61 miles from Knoxville to Anderson in southeast direction and 197 miles (317.04 kilometers) by car, following the I-40 route.
Knoxville and Anderson are 4 hours 15 mins far apart, if you drive non-stop.
This is the fastest route from Knoxville, TN to Anderson, SC. The halfway point is Canton, NC.
Knoxville, TN and Anderson, SC are in the same time zone (Eastern Daylight Time). Current time in both locations is 5:32 pm.
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