There are 243.84 miles from La Crosse to Afton in southwest direction and 344 miles (553.61 kilometers) by car, following the I-35 S route.
La Crosse and Afton are 5 hours 20 mins far apart, if you drive non-stop .
This is the fastest route from La Crosse, WI to Afton, IA. The halfway point is Clear Lake, IA.
La Crosse, WI and Afton, IA are in the same time zone (CDT). Current time in both locations is 9:16 am.
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