There are 137.57 miles from La Crosse to Knowles in east direction and 168 miles (270.37 kilometers) by car, following the I-90 and I-94 E route.
La Crosse and Knowles are 3 hours far apart, if you drive non-stop .
This is the fastest route from La Crosse, WI to Knowles, WI. The halfway point is Lyndon Station, WI.
La Crosse, WI and Knowles, WI are in the same time zone (CDT). Current time in both locations is 1:34 am.
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