There are 1,547.35 miles from La Crosse to Twain in west direction and 1,948 miles (3,135.00 kilometers) by car, following the I-80 route.
La Crosse and Twain are 1 day 3 hours far apart, if you drive non-stop .
This is the fastest route from La Crosse, WI to Twain, CA. The halfway point is Laramie, WY.
Please note the time difference between La Crosse, WI and Twain, CA is 2 hours. The current time in La Crosse is 4:19 am and the current time in Twain is 2:19 am.
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