There are 22.06 miles from Lake City to Knoxville in southeast direction and 26 miles (41.84 kilometers) by car, following the I-75 S route.
Lake City and Knoxville are 28 minutes far apart, if you drive non-stop .
This is the fastest route from Lake City, TN to Knoxville, TN. The halfway point is Heiskell, TN.
Lake City, TN and Knoxville, TN are in the same time zone (EDT). Current time in both locations is 7:39 pm.
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