There are 311.29 miles from Lexington to Saint Louis in west direction and 337.35 miles (542.91 kilometers) by car, following the I-64 route.
Lexington and Saint Louis are 5 hours 27 mins far apart, if you drive non-stop.
This is the fastest route from Lexington, KY to Saint Louis, MO. The halfway point is .
Please note the time difference between Lexington, KY and Saint Louis, MO is 1 hour. The current time in Lexington is 1:17 pm and the current time in Saint Louis is 12:17 pm.
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