There are 311.29 miles from Lexington to Saint Louis in west direction and 337 miles (542.35 kilometers) by car, following the I-64 route.
Lexington and Saint Louis are 6 hours 13 mins far apart, if you drive non-stop.
This is the fastest route from Lexington, KY to Saint Louis, MO. The halfway point is Lynnville, IN.
Please note the time difference between Lexington, KY and Saint Louis, MO is 1 hour. The current time in Lexington is 1:26 pm and the current time in Saint Louis is 12:26 pm.
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