There are 187.97 miles from Louisville to Knoxville in southeast direction and 246.04 miles (395.96 kilometers) by car, following the I-64 and I-75 route.
Louisville and Knoxville are 3 hours 34 mins far apart, if you drive non-stop.
This is the fastest route from Louisville, KY to Knoxville, TN. The halfway point is .
Louisville, KY and Knoxville, TN are in the same time zone (EDT). Current time in both locations is 11:29 am.
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