There are 187.97 miles from Louisville to Knoxville in southeast direction and 238 miles (383.02 kilometers) by car, following the I-75 route.
Louisville and Knoxville are 4 hours 31 mins far apart, if you drive non-stop.
This is the fastest route from Louisville, KY to Knoxville, TN. The halfway point is Brodhead, KY.
Louisville, KY and Knoxville, TN are in the same time zone (Eastern Daylight Time). Current time in both locations is 4:27 am.
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