There are 241.97 miles from Louisville to Saint Louis in west direction and 259.89 miles by car, following the route.
Louisville and Saint Louis are 3 hours 51 mins far apart, if you drive non-stop.
This is the fastest route from Louisville, KY to Saint Louis, MO. The halfway point is .
Please note the time difference between Louisville, KY and Saint Louis, MO is 1 hour. The current time in Louisville is 6:52 pm and the current time in Saint Louis is 5:52 pm.
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