There are 241.70 miles from Louisville to Saint Louis in west direction and 260 miles (418.43 kilometers) by car, following the I-64 route.
Louisville and Saint Louis are 4 hours 48 mins far apart, if you drive non-stop.
This is the fastest route from Louisville, KY to Saint Louis, MO. The halfway point is Grayville, IL.
Please note the time difference between Louisville, KY and Saint Louis, MO is 1 hour. The current time in Louisville is 7:35 am and the current time in Saint Louis is 6:35 am.
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