There are 1,181.90 miles from Mesa to Lafayette in east direction and 1,381 miles (2,222.50 kilometers) by car, following the I-10 route.
Mesa and Lafayette are 1 day far apart, if you drive non-stop.
This is the fastest route from Mesa, AZ to Lafayette, LA. The halfway point is Girvin, TX.
Please note the time difference between Mesa, AZ and Lafayette, LA is 2 hours. The current time in Mesa is 11:56 am and the current time in Lafayette is 1:56 pm.
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