There are 1,072.53 miles from Mesa to Sioux Falls in northeast direction and 1,511 miles (2,431.72 kilometers) by car, following the I-76 and US-6 route.
Mesa and Sioux Falls are 1 day 3 hours far apart, if you drive non-stop.
This is the fastest route from Mesa, AZ to Sioux Falls, SD. The halfway point is USAF Academy, CO.
Please note the time difference between Mesa, AZ and Sioux Falls, SD is 2 hours. The current time in Mesa is 5:21 pm and the current time in Sioux Falls is 7:21 pm.
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