There are 327.52 miles from Milwaukee to Saint Louis in southwest direction and 372.79 miles (599.95 kilometers) by car, following the I-55 route.
Milwaukee and Saint Louis are 6 hours 12 mins far apart, if you drive non-stop.
This is the fastest route from Milwaukee, WI to Saint Louis, MO. The halfway point is .
Milwaukee, WI and Saint Louis, MO are in the same time zone (CDT). Current time in both locations is 1:46 am.
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