There are 327.52 miles from Milwaukee to Saint Louis in southwest direction and 374 miles (601.89 kilometers) by car, following the I-55 S route.
Milwaukee and Saint Louis are 5 hours 53 mins far apart, if you drive non-stop .
This is the fastest route from Milwaukee, WI to Saint Louis, MO. The halfway point is Lexington, IL.
Milwaukee, WI and Saint Louis, MO are in the same time zone (CDT). Current time in both locations is 7:32 am.
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