There are 512.50 miles from New Castle to Waterloo in southwest direction and 625 miles (1,005.84 kilometers) by car, following the I-85 S route.
New Castle and Waterloo are 10 hours 6 mins far apart, if you drive non-stop .
This is the fastest route from New Castle, DE to Waterloo, SC. The halfway point is Middleburg, NC.
New Castle, DE and Waterloo, SC are in the same time zone (EDT). Current time in both locations is 8:37 pm.
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