There are 352.97 miles from New Castle to Wytheville in southwest direction and 408 miles (656.61 kilometers) by car, following the I-81 S route.
New Castle and Wytheville are 6 hours 28 mins far apart, if you drive non-stop .
This is the fastest route from New Castle, DE to Wytheville, VA. The halfway point is Edinburg, VA.
New Castle, DE and Wytheville, VA are in the same time zone (EDT). Current time in both locations is 9:17 am.
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