There are 305.21 miles from Orlando to Charleston in northeast direction and 378 miles (608.33 kilometers) by car, following the I-95 N route.
Orlando and Charleston are 6 hours 6 mins far apart, if you drive non-stop .
This is the fastest route from Orlando, FL to Charleston, SC. The halfway point is Waverly, GA.
Orlando, FL and Charleston, SC are in the same time zone (EDT). Current time in both locations is 2:37 am.
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