There are 107.49 miles from Orlando to Port Saint Lucie in southeast direction and 125.38 miles by car, following the route.
Orlando and Port Saint Lucie are 1 hour 51 mins far apart, if you drive non-stop.
This is the fastest route from Orlando, FL to Port Saint Lucie, FL. The halfway point is .
Orlando, FL and Port Saint Lucie, FL are in the same time zone (EDT). Current time in both locations is 3:46 pm.
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