There are miles from Osprey to Port Saint Lucie in east direction and miles by car, following the route.
Osprey and Port Saint Lucie are far apart, if you drive non-stop.
This is the fastest route from Osprey, FL to Port Saint Lucie, FL. The halfway point is .
Osprey, FL and Port Saint Lucie, FL are in the same time zone (EDT). Current time in both locations is 1:35 pm.
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