There are 550.60 miles from Philadelphia to Knoxville in southwest direction and 620 miles (997.79 kilometers) by car, following the I-81 S route.
Philadelphia and Knoxville are 9 hours 41 mins far apart, if you drive non-stop .
This is the fastest route from Philadelphia, PA to Knoxville, TN. The halfway point is Fairfield, VA.
Philadelphia, PA and Knoxville, TN are in the same time zone (EDT). Current time in both locations is 8:49 am.
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