Distance between cities › USA › Maryland › Poolesville, MD › Distance from Poolesville to Florence Book Hotels

Distance from Poolesville, MD to Florence, SC

Distance

428 mi

Time

8 hours 12 mins

Gas Cost

$40 - $78

There are 365.88 miles from Poolesville to Florence in southwest direction and 428 miles (688.80 kilometers) by car, following the I-95 route.

Poolesville and Florence are 8 hours 12 mins far apart, if you drive non-stop .

This is the fastest route from Poolesville, MD to Florence, SC. The halfway point is Weldon, NC.

Poolesville, MD and Florence, SC are in the same time zone (EDT). Current time in both locations is 9:27 am.

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Lowest Price Rental Cars in Poolesville, MD

Planning on renting a car to go from Poolesville, MD to Florence, SC? Here there are some offers to rent a car in Poolesville, MD

Small

From $14

Intermediate

From $18

Full-size

From $24

SUVs

From $28

Vans

From $40

Compare rental car prices in Poolesville »

Gas Consumption and Emissions

A car with a fuel efficiency of MPG will need 17.20 gallons of gas to cover the route between Poolesville, MD and Florence, SC.

The estimated cost of gas to go from Poolesville to Florence is $56.11.

During the route, an average car will release 336.99 pounds of CO₂ to the atmosphere. The carbon footprint would be 0.79 pounds of CO₂ per mile.

Average USA gas price used for calculation is $3.26 per gallon of regular gas. Price last updated on March 12, 2026.
Read more about our CO₂ calculation.

Halfway Point Between Poolesville, MD and Florence, SC

If you want to meet halfway between Poolesville, MD and Florence, SC or just make a stop in the middle of your trip, the exact coordinates of the halfway point of this route are 36.425549 and -77.634499, or 36º 25' 31.9764" N, 77º 38' 4.1964" W. This location is 214.14 miles away from Poolesville, MD and Florence, SC and it would take approximately 4 hours 6 mins to reach the halfway point from both locations.

Closest City or Town to Halfway Point

The closest town to the halfway point is Weldon, NC, situated 227 miles from Poolesville, MD and 214 miles from Florence, SC. It would take 3 hours 43 mins to go from Poolesville to Weldon and 3 hours 21 mins to go from Florence to Weldon.