There are 395.79 miles from Saint Louis to Columbus in northeast direction and 418 miles (672.71 kilometers) by car, following the I-70 route.
Saint Louis and Columbus are 6 hours 19 mins far apart, if you drive non-stop .
This is the fastest route from Saint Louis, MO to Columbus, OH. The halfway point is Eminence, IN.
Please note the time difference between Saint Louis, MO and Columbus, OH is 1 hour. The current time in Saint Louis is 5:51 pm and the current time in Columbus is 6:51 pm.
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