There are 273.21 miles from Saint Louis to Des Moines in northwest direction and 348.26 miles (560.47 kilometers) by car, following the US-34 and IA 163 route.
Saint Louis and Des Moines are 5 hours 28 mins far apart, if you drive non-stop.
This is the fastest route from Saint Louis, MO to Des Moines, IA. The halfway point is .
Saint Louis, MO and Des Moines, IA are in the same time zone (CDT). Current time in both locations is 4:12 am.
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