There are 751.08 miles from Saint Louis to Jacksonville in southeast direction and 899 miles (1,446.80 kilometers) by car, following the I-75 route.
Saint Louis and Jacksonville are 16 hours 35 mins far apart, if you drive non-stop.
This is the fastest route from Saint Louis, MO to Jacksonville, FL. The halfway point is Chattanooga, TN.
Please note the time difference between Saint Louis, MO and Jacksonville, FL is 1 hour. The current time in Saint Louis is 6:51 pm and the current time in Jacksonville is 7:51 pm.
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