There are 311.29 miles from Saint Louis to Lexington in east direction and 336 miles (540.74 kilometers) by car, following the I-64 route.
Saint Louis and Lexington are 6 hours 12 mins far apart, if you drive non-stop.
This is the fastest route from Saint Louis, MO to Lexington, KY. The halfway point is Lynnville, IN.
Please note the time difference between Saint Louis, MO and Lexington, KY is 1 hour. The current time in Saint Louis is 10:22 pm and the current time in Lexington is 11:22 pm.
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