There are 311.64 miles from Saint Louis to Lexington in east direction and 337.54 miles by car, following the route.
Saint Louis and Lexington are 5 hours 4 mins far apart, if you drive non-stop.
This is the fastest route from Saint Louis, MO to Lexington, KY. The halfway point is .
Please note the time difference between Saint Louis, MO and Lexington, KY is 1 hour. The current time in Saint Louis is 11:56 pm (May 27) and the current time in Lexington is 12:56 am (May 28).
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