There are 142.25 miles from San Diego to Simi Valley in northwest direction and 161.63 miles (260.12 kilometers) by car, following the I-5 route.
San Diego and Simi Valley are 2 hours 27 mins far apart, if you drive non-stop.
This is the fastest route from San Diego, CA to Simi Valley, CA. The halfway point is .
San Diego, CA and Simi Valley, CA are in the same time zone (PDT). Current time in both locations is 5:33 am.
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