There are 1,277.29 miles from Tucson to Murphysboro in northeast direction and 1,582.47 miles (2,546.74 kilometers) by car, following the I-40 route.
Tucson and Murphysboro are 22 hours 16 mins far apart, if you drive non-stop.
This is the fastest route from Tucson, AZ to Murphysboro, IL. The halfway point is .
Please note the time difference between Tucson, AZ and Murphysboro, IL is 2 hours. The current time in Tucson is 3:32 pm and the current time in Murphysboro is 5:32 pm.
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