There are 183.40 miles from Winston-Salem to Wilmington in southeast direction and 208 miles (334.74 kilometers) by car, following the US-421 route.
Winston-Salem and Wilmington are 4 hours 13 mins far apart, if you drive non-stop.
This is the fastest route from Winston-Salem, NC to Wilmington, NC. The halfway point is Spring Lake, NC.
Winston-Salem, NC and Wilmington, NC are in the same time zone (Eastern Daylight Time). Current time in both locations is 7:58 pm.
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