There are 299.14 miles from Boone to Issue in northeast direction and 397 miles (638.91 kilometers) by car, following the I-85 route.
Boone and Issue are 7 hours 59 mins far apart, if you drive non-stop .
This is the fastest route from Boone, NC to Issue, MD. The halfway point is Oxford, NC.
Boone, NC and Issue, MD are in the same time zone (EDT). Current time in both locations is 11:55 pm.
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