Distance between cities › USA › Missouri › Cascade, MO › Distance from Cascade to Hisle Book Hotels

Distance from Cascade, MO to Hisle, KY

Distance

421 mi

Time

9 hours 3 mins

Gas Cost

$39 - $76

There are 341.32 miles from Cascade to Hisle in east direction and 421 miles (677.53 kilometers) by car, following the Western Kentucky Parkway route.

Cascade and Hisle are 9 hours 3 mins far apart, if you drive non-stop .

This is the fastest route from Cascade, MO to Hisle, KY.

Please note the time difference between Cascade, MO and Hisle, KY is 1 hour. The current time in Cascade is 4:15 pm and the current time in Hisle is 5:15 pm.

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Lowest Price Rental Cars in Cascade, MO

Planning on renting a car to go from Cascade, MO to Hisle, KY? Here there are some offers to rent a car in Cascade, MO

Small

From $14

Intermediate

From $18

Full-size

From $24

SUVs

From $28

Vans

From $40

Compare rental car prices in Cascade »

Gas Consumption and Emissions

A car with a fuel efficiency of MPG will need 16.91 gallons of gas to cover the route between Cascade, MO and Hisle, KY.

The estimated cost of gas to go from Cascade to Hisle is $55.17.

During the route, an average car will release 331.38 pounds of CO₂ to the atmosphere. The carbon footprint would be 0.79 pounds of CO₂ per mile.

Average USA gas price used for calculation is $3.26 per gallon of regular gas. Price last updated on March 12, 2026.
Read more about our CO₂ calculation.

Halfway Point Between Cascade, MO and Hisle, KY

If you want to meet halfway between Cascade, MO and Hisle, KY or just make a stop in the middle of your trip, the exact coordinates of the halfway point of this route are 37.232063 and -87.285212, or 37º 13' 55.4268" N, 87º 17' 6.7632" W. This location is 210.58 miles away from Cascade, MO and Hisle, KY and it would take approximately 4 hours 31 mins to reach the halfway point from both locations.

Closest City or Town to Halfway Point

The closest town to the halfway point is Graham, KY, situated 215 miles from Cascade, MO and 209 miles from Hisle, KY. It would take 4 hours 41 mins to go from Cascade to Graham and 4 hours 26 mins to go from Hisle to Graham.