Distance between cities › USA › Missouri › Cascade, MO › Distance from Cascade to Mayersville Book Hotels

Distance from Cascade, MO to Mayersville, MS

Distance

376 mi

Time

8 hours 4 mins

Gas Cost

$35 - $68

There are 307.03 miles from Cascade to Mayersville in south direction and 376 miles (605.11 kilometers) by car, following the US-61 route.

Cascade and Mayersville are 8 hours 4 mins far apart, if you drive non-stop .

This is the fastest route from Cascade, MO to Mayersville, MS.

Cascade, MO and Mayersville, MS are in the same time zone (CDT). Current time in both locations is 5:38 am.

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Lowest Price Rental Cars in Cascade, MO

Planning on renting a car to go from Cascade, MO to Mayersville, MS? Here there are some offers to rent a car in Cascade, MO

Small

From $14

Intermediate

From $18

Full-size

From $24

SUVs

From $28

Vans

From $40

Compare rental car prices in Cascade »

Gas Consumption and Emissions

A car with a fuel efficiency of MPG will need 15.10 gallons of gas to cover the route between Cascade, MO and Mayersville, MS.

The estimated cost of gas to go from Cascade to Mayersville is $49.24.

During the route, an average car will release 295.77 pounds of CO₂ to the atmosphere. The carbon footprint would be 0.79 pounds of CO₂ per mile.

Average USA gas price used for calculation is $3.26 per gallon of regular gas. Price last updated on March 12, 2026.
Read more about our CO₂ calculation.

Halfway Point Between Cascade, MO and Mayersville, MS

If you want to meet halfway between Cascade, MO and Mayersville, MS or just make a stop in the middle of your trip, the exact coordinates of the halfway point of this route are 35.145459 and -90.122197, or 35º 8' 43.6524" N, 90º 7' 19.9092" W. This location is 187.95 miles away from Cascade, MO and Mayersville, MS and it would take approximately 4 hours 2 mins to reach the halfway point from both locations.

Closest City or Town to Halfway Point

The closest town to the halfway point is West Memphis, AR, situated 184 miles from Cascade, MO and 193 miles from Mayersville, MS. It would take 4 hours 1 min to go from Cascade to West Memphis and 4 hours 7 mins to go from Mayersville to West Memphis.

Major City Closest to Halfway Point

The major city closest to the halfway point between Cascade, MO and Mayersville, MS is Memphis, TN, situated 191 miles from Cascade, MO and 187 miles from Mayersville, MS. It would take 4 hours 8 mins to go from Cascade to Memphis and 4 hours to go from Mayersville to Memphis.